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KMID : 1037120130310020141
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The World Journal of Men′s Health
2013 Volume.31 No. 2 p.141 ~ p.149
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Effects of Sesame Oil on the Reproductive Parameters of Diabetes Mellitus-Induced Male Rats
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Abbasi Zahra
Tabatabaei Seyed Reza Fatemi
Mazaheri Yazdan
Barati Farid
Morovvati Hasan
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Abstract
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Purpose: The purpose of the present study was to investigate the effect of sesame oil on the reproductive parameters of diabetic male Wistar rats.
Materials and Methods: The adult male rats in a split plot design were divided into normal (n=10), normal 5% (n=5; 5% sesame oil enriched diet), diabetic (Streptozocin induced diabetes; n=9), diabetic 5% (n=9; 5% sesame oil enriched diet), and diabetic 10% (n=9; 10% sesame oil enriched diet) groups. Diet supplementation continued for 56 days.
Results: Sesame oil supplementation did not reduce the plasma glucose concentration of rats in the diabetic groups (p＞0.05). The total spermatogonia, spermatocytes, Leydig cells/tubule, and the germ cell to Sertoli cell ratio were lower in the diabetic rats than the normal ones (p＜0.05), and with the exception of spermatogonia counts, these values improved by the addition of sesame oil to the diet (p＜0.05). The sperm progressive motility and viability were lower in the diabetic rats (p＜0.05) and sesame oil supplementation did not improve them. Incorporation of sesame oil into the diet improved the plasma testosterone concentration of the diabetic rats in a dose-dependent manner (p＜0.05).
Conclusions: In summary, sesame oil supplementation improved the reproductive parameters of diabetic rats at the levels of the testicular microstructure and function, but was not effective in protecting the epididymal sperm.
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KEYWORD
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Rats, Diabetes mellitus, Spermatozoa, Testis, Testosterone, Sesame oil
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